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Related Experiment Video

Updated: Jun 4, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Genotyping of apolipoprotein e.

I C Ozturk¹, N Akel, A A Killeen

¹Department of Pathology, University, of Michigan, Ann Arbor, MI.

Methods in Molecular Medicine

|March 4, 2011

Summary

This summary is machine-generated.

Apolipoprotein E (apo E) is a plasma protein crucial for cholesterol transport. It is found in various lipoproteins, playing a key role in lipid metabolism.

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Area of Science:

Biochemistry
Lipid Metabolism

Background:

Apolipoprotein E (apo E) is a significant plasma protein.
It plays a critical role in the transport of cholesterol.
Apo E is associated with multiple lipoprotein classes.

Purpose of the Study:

To elucidate the role of Apolipoprotein E in cholesterol transport.
To detail the association of apo E with different lipoproteins.

Main Methods:

Characterization of apo E structure and function.
Lipoprotein analysis to determine apo E presence.

Main Results:

Apolipoprotein E is a 299-amino acid protein.
Confirmed the presence of apo E in chylomicrons, VLDL, IDL, and HDL.

Conclusions:

Apolipoprotein E is integral to cholesterol transport mechanisms.
Its distribution across various lipoproteins highlights its systemic role in lipid regulation.