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Related Concept Videos

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
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Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Eukaryotic Compartmentalizations

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
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Related Experiment Video

Updated: Jun 4, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

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Published on: June 2, 2015

Microencapsulation of enzymes, cells, and genetically engineered microorganisms.

T M Chang1

  • 1Artificial Cells and Organs Research Center, McGill University, Montreal, Quebec, Canada.

Methods in Molecular Medicine
|March 4, 2011
PubMed
Summary

Artificial cells, developed since 1964, are increasingly advanced. Recent research focuses on artificial cells for blood substitutes, enzyme therapy, and cell therapy applications.

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Last Updated: Jun 4, 2026

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Area of Science:

  • Biomaterials Science
  • Biotechnology
  • Regenerative Medicine

Background:

  • The concept of microencapsulating biologically active materials into artificial cells dates back to 1964.
  • Extensive development in artificial cell technology has occurred over the last decade.
  • Recent advancements focus on specific therapeutic applications.

Purpose of the Study:

  • To highlight recent advancements in artificial cell technology.
  • To showcase applications in blood substitutes, enzyme therapy, and cell therapy.
  • To provide examples of developed artificial cell systems.

Main Methods:

  • Microencapsulation techniques for creating artificial cells.
  • Development of artificial cells for specific biomedical applications.
  • Focus on three key areas: blood substitutes, enzyme therapy, and cell therapy.

Main Results:

  • Demonstrated feasibility of artificial cells for various therapeutic uses.
  • Progress in developing artificial cells for blood substitutes.
  • Advancements in enzyme and cell therapy using artificial cell technology.

Conclusions:

  • Artificial cell technology has matured significantly since its inception.
  • The technology holds promise for diverse therapeutic applications, including blood substitutes, enzyme, and cell therapies.
  • Further development is ongoing for specialized applications.