Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
Modeling with Differential Equations01:25

Modeling with Differential Equations

Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...
Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microencapsulated islet allografts in diabetic NOD mice and nonhuman primates.

European review for medical and pharmacological sciences·2020
Same author

Enrichment of IL-17A<sup>+</sup> IFN-γ<sup>+</sup> and IL-22<sup>+</sup> IFN-γ<sup>+</sup> T cell subsets is associated with reduction of NKp44<sup>+</sup> ILC3s in the terminal ileum of Crohn's disease patients.

Clinical and experimental immunology·2017
Same author

Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Peristance of bacteria in the presence of viable, nonencysting, bacterivorous ciliates.

Microbial ecology·2013
Same author

Changes in metabolism and hormone trafficking during exposure of endocrine cells to elevated ammonium.

Cytotechnology·2012
Same author

Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases.

Restorative neurology and neuroscience·2011
Same journal

Erratum to: Immunotherapeutic Approach to Cancer with Cutaneous DNA Vaccination.

Methods in molecular medicine·2015
Same journal

Methods for cancer gene therapy using tumor suppressor genes.

Methods in molecular medicine·2014
Same journal

Suppression of the human carcinoma phenotype by an antioncogene ribozyme.

Methods in molecular medicine·2014
Same journal

Methods for the use of stromal cells for therapeutic gene therapy.

Methods in molecular medicine·2014
Same journal

Methods for adenovirus-mediated gene transfer to synovium in vivo.

Methods in molecular medicine·2014
Same journal

Methods for gene transfer to synovium.

Methods in molecular medicine·2014
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Quantitative modeling of limitations caused by diffusion.

A Sambanis1, S A Tan

  • 1School of Chemical Engineering and Parker H.Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.

Methods in Molecular Medicine
|March 4, 2011
PubMed
Summary
This summary is machine-generated.

Nutrient transport in bioartificial tissues depends on diffusion. Quantifying diffusion rates is crucial for designing 3D cell-polymer systems and understanding their internal chemical environment.

More Related Videos

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Related Experiment Videos

Last Updated: Jun 4, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Chemical Engineering

Background:

  • Nutrient and metabolite transport in bioartificial tissues is primarily diffusion-driven.
  • Diffusion relies on concentration gradients between the construct interior and exterior.
  • Effective transport is vital for cell viability and function within engineered tissues.

Purpose of the Study:

  • To emphasize the critical role of diffusion in bioartificial tissue constructs.
  • To highlight the necessity of quantitatively evaluating diffusional processes.
  • To underscore the importance of diffusion assessment for construct design and chemical environment evaluation.

Main Methods:

  • This study focuses on the theoretical and quantitative aspects of diffusion.
  • No specific experimental methods are detailed in the abstract.
  • The evaluation involves assessing the rate of diffusional processes.

Main Results:

  • Diffusion is the exclusive transport mechanism for nutrients and metabolites in many constructs.
  • Quantitative evaluation of diffusion rates is essential for design.
  • Understanding diffusion aids in assessing the chemical environment within the construct.

Conclusions:

  • Accurate quantification of diffusion is paramount for successful bioartificial tissue engineering.
  • Diffusion limitations must be considered in the design of 3D cell-polymer systems.
  • Assessing diffusional transport is key to predicting and controlling the internal milieu of engineered tissues.