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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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The inflammation hypothesis in geriatric depression.

George S Alexopoulos1, Sarah Shizuko Morimoto

  • 1Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York, USA. gsalexop@med.cornell.edu.

International Journal of Geriatric Psychiatry
|March 4, 2011
PubMed
Summary
This summary is machine-generated.

Aging triggers immune system changes that may contribute to geriatric depression. This review explores the link between inflammation and depression in older adults, suggesting new treatment avenues.

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Area of Science:

  • Geriatric Psychiatry
  • Immunology
  • Neuroscience

Background:

  • Geriatric depression etiology remains unclear despite research on brain abnormalities.
  • This study investigates immune deregulation linked to aging and disease as a cause of geriatric depression.

Purpose of the Study:

  • To examine the role of age-related and comorbid disease-related immune deregulation in geriatric depression.
  • To review the interplay between neuroinflammation, aging, depression, and anti-inflammatory treatments.

Main Methods:

  • Literature review of neuroinflammation in aging and depression.
  • Analysis of studies on antidepressant and anti-inflammatory agent actions.

Main Results:

  • Aging increases peripheral immune responses and shifts the central nervous system (CNS) to a pro-inflammatory state.
  • These immune changes may alter emotional/cognitive networks, causing geriatric depression symptoms.
  • Some antidepressants and anti-inflammatory agents show potential therapeutic effects.

Conclusions:

  • Inflammatory processes associated with aging and disease may predispose individuals to geriatric depression.
  • The 'inflammation hypothesis' offers testable pathways for understanding and treating geriatric depression.
  • This research may foster novel treatments using anti-inflammatory pharmacology for depressed elderly patients.