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Related Experiment Video

Updated: Jun 4, 2026

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

Laryngeal regeneration using tissue engineering techniques in a canine model.

Yoshiharu Kitani¹, Shin-Ichi Kanemaru, Hiroo Umeda

¹Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The Annals of Otology, Rhinology, and Laryngology

|March 5, 2011

Summary

The 3% collagen-coated polypropylene mesh scaffold shows promise for laryngeal regeneration after partial hemilaryngectomy in dogs. This biomaterial facilitated better vocal fold morphology and reduced mesh exposure compared to 1% collagen coating.

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Last Updated: Jun 4, 2026

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Area of Science:

Regenerative Medicine
Biomaterials Science
Otorhinolaryngology

Background:

Polypropylene mesh coated with collagen sponge has previously shown utility in trachea and cricoid cartilage regeneration.
Laryngeal regeneration remains a challenge after partial hemilaryngectomy.

Purpose of the Study:

To evaluate the efficacy of a 3% collagen-coated polypropylene mesh scaffold wrapped in fascia lata for laryngeal regeneration following partial hemilaryngectomy.

Main Methods:

A left partial hemilaryngectomy was performed on 12 beagles.
Polypropylene mesh scaffolds coated with 1% or 3% collagen sponge were used.
Scaffolds were wrapped in autologous fascia lata and implanted into the laryngeal defect.
Endoscopic examinations, 3D CT scans, and vibratory assessments were conducted post-implantation.

Main Results:

The 3% collagen group exhibited no mesh exposure or dislocation, unlike the 1% group (3/6 cases).
Superior morphological findings of the vocal fold were observed in the 3% collagen group.
Vertical level differences in vocal folds were noted in both groups.

Conclusions:

A 3% collagen-coated polypropylene mesh scaffold, augmented with autologous fascia, is a viable biomaterial for laryngeal regeneration.
The 3% collagen concentration appears to enhance scaffold integration and tissue morphology compared to 1% concentration.