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Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Urticaria due to antihistamines.

L Sánchez Morillas¹, P Rojas Pérez-Ezquerra, M Reaño Martos

¹Allergology Department, Hospital Central de la Cruz Roja, Madrid, Spain. lsanchezmorillas@hotmail.com

Journal of Investigational Allergology & Clinical Immunology

|March 5, 2011

Summary

This study details a rare case of urticaria caused by common H1-antihistamines like ebastine and fexofenadine. Diagnosis was confirmed through oral challenges, highlighting potential drug-induced hypersensitivity.

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Area of Science:

Allergy and Immunology
Pharmacology

Background:

H1-antihistamines are mainstays in treating allergic diseases, known for their safety and efficacy.
Drug hypersensitivity reactions, including urticaria, can occur despite a favorable safety profile.

Observation:

A patient developed urticaria after ingesting ebastine and fexofenadine.
Standard allergy tests (skin prick, patch, basophil activation) were negative for the implicated drugs and other antihistamines.

Findings:

Oral challenges confirmed hypersensitivity to ebastine and fexofenadine, as well as other tested antihistamines.
The patient tolerated cetirizine during an oral challenge, indicating selective tolerance.

Implications:

This case highlights the possibility of antihistamine-induced urticaria, even with commonly used medications.
The underlying mechanism of sensitization to these H1-antihistamines requires further investigation.