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Factor H.

D P Vik1, P Muñoz-Cánoves, D D Chaplin

  • 1Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.

Current Topics in Microbiology and Immunology
|January 1, 1990
PubMed
Summary
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Mouse and human H proteins share structure and function but differ genetically. Mice possess at least three H genes, unlike humans, indicating genetic complexity in murine H locus evolution.

Area of Science:

  • Genetics
  • Molecular Biology
  • Comparative Genomics

Background:

  • Human and mouse H proteins exhibit structural and functional similarities.
  • Genetic analysis reveals significant divergence between human and mouse H protein genes.
  • The H locus in mice is known to be genetically complex.

Purpose of the Study:

  • To investigate the genetic basis of H protein differences between mice and humans.
  • To characterize the murine H locus and identify the number of related genes.
  • To compare the genetic organization of the H locus with other related gene families.

Main Methods:

  • cDNA sequencing was employed to analyze H protein genes.
  • Hybridization analysis of genomic cosmid clones was performed.

Related Experiment Videos

  • Comparative genomic analysis was conducted to identify related genes and their locations.

    • Main Results:

    • At least three distinct, highly related genes were identified within the mouse H locus.
    • The consensus repeating unit of the H protein molecule is extensively duplicated.
    • Evidence suggests similar genetic complexity in other related gene families, such as human CR1 and mouse mCRY.

    Conclusions:

    • The murine H locus is genetically complex, containing multiple related genes.
    • Gene duplication events contribute to the complexity of the H locus.
    • Further research is warranted to explore the genetic locus complexity in other H protein family members.