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The calcium ATPase of sarcoplasmic reticulum is inhibited by one Ca2+ ion
D Khananshvili1, J Myung, R Kolouch
1Graduate Department of Biochemistry, Brandeis University, Waltham, MA 02254.
FEBS Letters
|January 15, 1990
Abstract:
Inhibition by calcium of the steady-state turnover of the calcium ATPase from sarcoplasmic reticulum of rabbit muscle follows a Hill slope of 0.8 +/- 0.2 (pH 7.0, 0.1 M KCl, varying [Mg2+] and 2 microM A23187 ionophore). It is concluded that dissociation of the two Ca2+ ions from E-P.Ca2 is sequential and that the inhibition arises from the binding of one Ca2+ to A-P.Ca1.