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Updated: Jun 4, 2026
High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
Published on: November 8, 2018
Uncertainty in nuchal translucency reference ranges at 11-14 weeks of gestation--comparison to Swedish centiles
Marius Kublickas1, Sissel Saltvedt, Harald Almström
1Center of Fetal Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden. marius.kublickas@ki.se
Objective:
To generate a regression equation for the nuchal translucency (NT) median for the Swedish population and compare this with other median values.
Setting:
Eight Swedish hospitals.
Sample:
The data set included 20 887 unaffected fetuses.
Methods:
Calculation and generation of an NT centile chart for the Swedish population.
Results:
The NT centiles for crown-rump length (CRL) from 45 to 84 mm were calculated and compared with the medians from Glasgow, from the Fetal Medicine Foundation (FMF, London, UK; FMF-original) and those published recently (FMF-new). The NT medians cease to increase at CRLs between 70 and 75 mm. The Swedish, FMF-new and Glasgow medians followed the same pattern, but the Glasgow NT median curve was systematically lower by around 20%. Swedish, FMF-new and Glasgow medians differed in shape from the FMF-original medians, which continuously increase throughout the whole range of CRLs.
Conclusions:
Our results demonstrate that there are substantial differences in the NT medians and centiles between countries.
