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A consensus statement on clinical trials of bypassing agent prophylaxis in inhibitor patients
J Teitel1, E Berntorp, G Dolan
1St Michael's Hospital, Department of Medicine and University of Toronto, Toronto, ON, Canada. teitelj@smh.ca
Abstract:
The haemophilia literature increasingly contains reports describing the use of bypassing agent prophylaxis (BAP) in patients with severe haemophilia A and inhibitors. However, it is difficult to interpret and compare the results and draw conclusions about treatment efficacy because of small patient numbers and a lack of standardization among BAP studies. This article presents consensus recommendations for standardizing future BAP clinical trials developed by an international panel of haemophilia opinion leaders.
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