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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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Coronary Artery Disease IV: Preventive Measures

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Ischemic Stroke ll: Pathophysiology01:15

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Related Experiment Video

Updated: Jun 4, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Preventive antibiotics in stroke study: rationale and protocol for a randomised trial.

Paul J Nederkoorn1, Willeke F Westendorp, Imke J Hooijenga

  • 1Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands Clinical Research Unit, Academic Medical Center, Amsterdam, The Netherlands. p.j.nederkoorn@amc.uva.nl

International Journal of Stroke : Official Journal of the International Stroke Society
|March 5, 2011
PubMed
Summary

Preventive antibiotic therapy with ceftriaxone may improve functional outcomes for stroke patients. This randomized trial will compare ceftriaxone prophylaxis against standard care to assess its impact on recovery and reduce infection rates.

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Prehospital Thrombolysis: A Manual from Berlin
05:52

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Published on: November 26, 2013

Related Experiment Videos

Last Updated: Jun 4, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Stroke is a leading global cause of mortality.
  • Fever and infections post-stroke are linked to poorer patient outcomes.
  • Preventive antibiotics may reduce infection rates in stroke patients.

Purpose of the Study:

  • To determine if preventive ceftriaxone improves functional outcomes in stroke patients.
  • To evaluate the efficacy of early antibiotic prophylaxis in acute stroke care.

Main Methods:

  • A multicenter, prospective, randomized, open-label trial comparing standard care with preventive ceftriaxone to standard care alone.
  • Inclusion of 3200 adult patients with ischemic or hemorrhagic stroke (NIHSS score ≥ 1).
  • Administration of 2g ceftriaxone intravenously every 24 hours for four days in the treatment group.

Main Results:

  • Primary endpoint: functional outcome at 3 months (modified Rankin Scale 0-2 vs. 3-6).
  • Secondary endpoints include mortality, infection rates, hospital length of stay, and quality-adjusted life years.
  • Analysis will compare outcomes between the ceftriaxone prophylaxis group and the standard care group.

Conclusions:

  • This trial aims to provide crucial evidence on the clinical utility of preventive ceftriaxone in stroke management.
  • Findings will inform guidelines regarding antibiotic use to improve stroke patient recovery.
  • The study is powered to detect significant differences in functional outcomes and other key clinical markers.