Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Menstrual dysfunction in hirsute women.

G P Redmond1, W Bergfeld, M Gupta

  • 1Department of Endocrinology, Cleveland Clinic Foundation, OH 44195.

Journal of the American Academy of Dermatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconsidering rationality and ethics in the evidence-based medicine debate: a reply to commentators.

Journal of evaluation in clinical practice·2004
Same author

Spontaneous resolution of a choroidal mass.

Eye (London, England)·2004
Same author

Screening for visual impairment in elderly patients with hip fracture: validating a simple bedside test.

Eye (London, England)·2004
Same author

Bovine pericardium (Ocuguard) wrap for hydroxyapatite implants.

The British journal of ophthalmology·2004
Same author

Inhibition of skin sphingosine synthesis: enhanced percutaneous permeation of 5-fluorouracil.

Die Pharmazie·2004
Same author

Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice.

Methods and findings in experimental and clinical pharmacology·2004

Hirsute women with abnormal menstrual cycles showed significantly higher levels of total and free testosterone, and androstenedione compared to those with normal cycles. This suggests more severe endocrine abnormalities in hirsute women with irregular menses.

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Women's Health

Background:

  • Hirsutism in women is often linked to elevated androgens, but biochemical findings vary.
  • Previous studies have reported conflicting results regarding androgen levels in hirsute women.

Purpose of the Study:

  • To compare biochemical findings in hirsute women with normal versus abnormal menstrual cycles.
  • To investigate the relationship between menstrual irregularities and androgen levels in hirsutism.

Main Methods:

  • Compared 30 hirsute women with normal menses to 30 hirsute women with abnormal cycles.
  • Measured levels of total testosterone, free testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS).
  • Assessed levels of thyroxin, thyrotropin, and prolactin.

Related Experiment Videos

Main Results:

  • The abnormal menstruation group had higher mean body weight.
  • Significantly higher total testosterone (p=0.004) and free testosterone (p=0.002) levels were observed in the abnormal group.
  • The abnormal group tended to have higher androstenedione levels, while DHEAS levels were similar.

Conclusions:

  • Hirsute women with abnormal menses tend to be heavier and exhibit more severe endocrine abnormalities, including higher androgen levels.
  • Findings support the clinical impression of a more pronounced endocrine derangement in hirsute women with irregular cycles.