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Related Experiment Videos

Circadian-based infusional FUDR therapy.

R M Lanning, R von Roemeling, W J Hrushesky

    Oncology Nursing Forum
    |January 1, 1990
    PubMed
    Summary

    Circadian-modified infusion of 5-fluoro-2'-deoxyuridine (FUDR) reduces severe gastrointestinal toxicity in metastatic renal cell cancer patients. This optimized delivery allows for increased FUDR dosage, potentially enhancing anti-tumor activity.

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    Area of Science:

    • Oncology
    • Pharmacology
    • Biomedical Engineering

    Background:

    • Metastatic renal cell cancer (RCC) treatment options are limited.
    • 5-fluoro-2 eal-deoxyuridine (FUDR) shows activity against metastatic RCC.
    • Continuous intravenous infusion of FUDR can cause severe, life-threatening gastrointestinal toxicity.

    Purpose of the Study:

    • To evaluate the safety and efficacy of a novel circadian-modified infusion of FUDR in metastatic RCC patients.
    • To assess the potential for increased FUDR dosage and anti-tumor activity with optimized delivery.
    • To explore the role of programmable infusion systems in managing complex chemotherapy regimens.

    Main Methods:

    • Phase I studies involving 54 patients treated with intravenous FUDR.
    • Phase II study utilizing circadian-modified intravenous FUDR delivery in 61 metastatic RCC patients.
    • Implementation of the programmable, implantable Synchro-Med Infusion System for automated drug administration.

    Main Results:

    • Circadian modification of FUDR infusion significantly reduced gastrointestinal toxicity.
    • The modified infusion allowed for safe escalation of FUDR dosage.
    • Improved toxicity profile may lead to enhanced anti-tumor efficacy in metastatic RCC.

    Conclusions:

    • Circadian-modified FUDR infusion is a viable strategy to mitigate toxicity in metastatic RCC.
    • Programmable infusion systems facilitate complex chemotherapy delivery and dose optimization.
    • Nursing management is crucial for patient safety and effective treatment with implantable drug delivery systems.

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