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Related Experiment Video

Updated: Jun 3, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

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Published on: January 7, 2019

Barthel index for stroke trials: development, properties, and application.

Terence J Quinn1, Peter Langhorne, David J Stott

  • 1Department of Academic Geriatric Medicine, Institute of Cardiovascular and Medical Services, University of Glasgow, UK. Terry.quinn@glasgow.ac.uk

Stroke
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

The Barthel index (BI) is a common measure in stroke trials, but its validity and reliability vary. Standardizing the 10-item BI scale is recommended for consistent functional outcome assessment in stroke research.

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Last Updated: Jun 3, 2026

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Published on: July 14, 2023

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Functional outcome measures are crucial for evaluating stroke treatment efficacy.
  • The Barthel index (BI) is frequently used in stroke clinical trials.

Purpose of the Study:

  • To review the clinimetric properties of the Barthel index (BI) in stroke trials.
  • To assess the validity, reliability, and responsiveness of the BI.

Main Methods:

  • A narrative review of published literature was conducted.
  • Studies examining the BI's clinimetric properties or its use as a stroke trial endpoint were included.

Main Results:

  • Evidence supports the BI's validity for measuring activities of daily living.
  • Reliability is generally acceptable, but sensitivity to change is limited at disability extremes (floor/ceiling effects).
  • Methodological heterogeneity and variations in BI scale content pose limitations.

Conclusions:

  • Despite available literature, questions persist regarding the BI's clinimetric properties.
  • Greater consistency in BI methodology, content, and scoring is needed.
  • A standardized 10-item BI scale is proposed as the uniform measure for stroke trials.