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The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
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Related Experiment Video

Updated: Jun 3, 2026

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

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Published on: November 27, 2015

Ceramicines E-I, new limonoids from Chisocheton ceramicus.

Chin Piow Wong1, Misae Shimada, Yuta Nagakura

  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

Chemical & Pharmaceutical Bulletin
|March 5, 2011
PubMed
Summary

Five new compounds called ceramicines E-I were discovered in Chisocheton ceramicus bark. These natural products show moderate activity against cancer cell growth, offering potential for new drug development.

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Chisocheton ceramicus is a plant source of bioactive compounds.
  • Limonoids are a class of terpenoids with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new limonoids from Chisocheton ceramicus.
  • To evaluate the cytotoxic activities of the isolated compounds.
  • To determine the absolute structure of a known related compound.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy.
  • Cytotoxicity assays against various human cancer cell lines.
  • Circular Dichroism (CD) and X-ray crystallography for absolute structure determination.

Main Results:

  • Five new limonoids, ceramicines E-I (1-5), were successfully isolated and identified.
  • Compounds 1-5 demonstrated moderate inhibitory effects on the proliferation of HL-60, A549, MCF7, and HCT116 cell lines.
  • The absolute structure of ceramicine B (6) was definitively established.

Conclusions:

  • The bark of Chisocheton ceramicus yields novel limonoids with potential anticancer properties.
  • Ceramicines E-I represent a new series of cytotoxic natural products.
  • Further investigation into these compounds may lead to the development of new therapeutic agents.