Related Experiment Video
Updated: Jun 3, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
Tuberculous encephalopathy without meningitis: pathology and brain MRI findings
Hee-Jin Kim1, Kyu-Won Shim, Moon-Kyu Lee
1Department of Neurology, Yonsei University College of Medicine, 134 Sinchon-dong, Seoul, Republic of Korea.
Abstract:
Tuberculous encephalopathy (TBE) is an established disease entity of diffuse cerebral damage occurring with tuberculosis and an underlying immune pathogenesis. However, the presence of this disease entity remains controversial. We report a 15-year-old boy with seizures and a progressive decline of cognitive function. Brain MRI showed diffuse, hyperintense lesions in the white matter on a T2-weighted image, with gadolinium enhancement on a T1-weighted image. Brain biopsy revealed demyelination and granuloma in the white matter. Ziehl-Neelsen staining showed acid-fast bacilli in the granulomas. Antituberculous medication with concomitant steroid treatment resulted in radiological resolution in addition to clinical improvement. Clinicopathological evidence in this case provides additional convincing evidence of TBE as a disease entity distinct from tuberculous meningitis.
Related Concept Videos
Encephalitis ll: Pathophysiology
Brain Abscess l: Introduction
Encephalitis l: Introduction
Bacterial Meningitis II: Pathophysiology
Bacterial Meningitis I: Introduction
Viral Meningitis

