Related Experiment Video

Updated: Jun 3, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Proteomic approach to the study of statin pleiotropy in kidney transplant patients

Vanessa Pérez1, Maribel Navarro-Muñoz, Sebastián Mas

  • 1Department of Nephrology, Germans Trias i Pujol University Hospital, Autonomous University of Barcelona, Barcelona, Spain.

Pharmacology
|March 5, 2011
PubMed
Abstract

Insights

Atorvastatin therapy in kidney transplant recipients improved lipid profiles and reduced inflammatory peptides, suggesting potential anti-inflammatory benefits. This study explored its effects on lipid profile, renal function, and plasma peptides.

Area of Science:

  • Nephrology
  • Pharmacology
  • Proteomics

Background:

  • Dyslipidemia is common in kidney transplant recipients.
  • Statins manage dyslipidemia and possess pleiotropic effects.
  • Kidney transplant patients often require lipid management.

Purpose of the Study:

  • To evaluate the impact of atorvastatin on lipid profile, renal function, inflammation markers, and plasma peptides in kidney transplant recipients.
  • To investigate the anti-inflammatory effects of atorvastatin therapy.
  • To analyze changes in the plasma peptide profile after 12 weeks of atorvastatin treatment.

Main Methods:

  • A 12-week study involving 54 kidney transplant patients receiving 10 mg/day atorvastatin.
  • Biochemical variables analyzed using a routine clinical laboratory analyzer.
  • Proteomic analysis performed using magnetic particle-assisted sample processing and mass spectrometry.

Main Results:

  • Atorvastatin therapy significantly improved the lipid profile.
  • Plasma peptide profile showed significant changes post-treatment.
  • Decreased peptides (m/z 1063 and 1898) identified as fragments of high-molecular-weight kininogen and complement factor C4, respectively, indicating reduced vascular inflammation.

Conclusions:

  • Atorvastatin demonstrates anti-inflammatory actions in kidney transplant recipients.
  • These findings support the role of statins in improving the clinical status of these patients.
  • The study contributes evidence for the pleiotropic, anti-inflammatory effects of statins.

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Hepatic Drug Clearance: Effect of Protein Binding01:09

Hepatic Drug Clearance: Effect of Protein Binding

Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...