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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 3, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Update on Crohn's disease: a polymorphic entity.

A Sartini1, L Castellani, F Buonfiglioli

  • 1Department of Clinical Medicine, University of Bologna, Bologna, Italy. ale.sartini@gmail.com

Minerva Gastroenterologica E Dietologica
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract. Its development involves genetic predisposition and immune system dysfunction, presenting diverse clinical and histopathological features.

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Crohn's disease is a chronic transmural inflammatory condition impacting the gastrointestinal tract, with higher incidence in industrialized nations.
  • Environmental factors and infectious agents are implicated, but disease development likely requires genetic predisposition and immune system dysregulation.

Purpose of the Study:

  • To provide a comprehensive overview of Crohn's disease, encompassing its epidemiology, pathogenesis, clinical presentation, histopathology, and management.
  • To highlight the polymorphic nature of Crohn's disease and the importance of accurate diagnosis and tailored treatment.

Main Methods:

  • Review of existing literature on Crohn's disease.
  • Analysis of histopathological findings, including mucosal hyperemia, ulcerations, and granuloma formation.
  • Correlation of clinical symptoms (diarrhea, abdominal pain) and extraintestinal manifestations with disease severity.

Main Results:

  • Histopathology reveals characteristic features such as 'cobblestone' appearance in severe cases and cryptic abscesses.
  • Common symptoms include chronic diarrhea and abdominal pain, with potential ocular and articular complications.
  • Treatment strategies are individualized based on clinical presentation and disease characteristics.

Conclusions:

  • Crohn's disease is a complex entity with varied clinical and histopathological manifestations.
  • Accurate diagnostic testing and a deep understanding of the disease's multifaceted aspects are crucial for effective patient management.