Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Acute Myocardial Infarction in Rats

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

Acute myocardial infarction in rats.

Yewen Wu¹, Xing Yin, Cori Wijaya

¹Department of Internal Medicine, Division of Cardiology, University of Texas Medical Branch, USA.

Journal of Visualized Experiments : Jove

|March 5, 2011

Summary

This study details a rat model of acute myocardial infarction (AMI) to investigate heart failure. The model mimics human cardiac disease, aiding research into therapeutic strategies for cardiovascular conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

STEMIN- and YAP5SA-induced exosomes prevent cardiomyocyte apoptosis.

iScience·2026

Same author

K<sub>2</sub>P Channels as Key Regulators of Cardiovascular and Pulmonary Vascular Function.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Fibro-Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin.

Journal of cachexia, sarcopenia and muscle·2026

Same author

Vascular Smooth Muscle-Specific NLRP3 Hyperactivation Drives Arterial Intimal Hyperplasia in Mice.

Research square·2026

Same author

Phosphodiesterase 8 regulation of excitation-contraction coupling as a target for cardiovascular disease: is it my turn now?

American journal of physiology. Heart and circulatory physiology·2026

Same author

Risk factors for paternal perinatal depression in Chinese advanced maternal age couples: A regression mixture model.

World journal of psychiatry·2026

Area of Science:

Biomedical research
Cardiovascular disease research
Animal models in cardiology

Background:

Heart failure is a leading cause of death in the USA, necessitating advancements in cardiovascular disease treatments.
Myocardial infarction (MI) and ischemia-reperfusion (IR) are key models for studying heart failure and cardiac remodeling.
The progression of left ventricular (LV) dysfunction in rat MI models mirrors that in human heart failure patients.

Purpose of the Study:

To present and validate a rat model of acute myocardial infarction (AMI) for studying cardiovascular disease.
To assess the utility of the AMI model in understanding cardiac signaling mechanisms and evaluating therapeutic strategies for heart failure.
To detail methods for assessing infarct size and area-at-risk in the AMI model.

Main Methods:

Related Experiment Videos

Last Updated: Jun 3, 2026

Acute Myocardial Infarction in Rats

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

Induction of AMI in rats via a 30-minute ligation of the left anterior descending artery (LAD), followed by reperfusion.
Assessment of infarct size and area-at-risk (AAR) using Evan's blue dye and triphenyl tetrazolium chloride (TTC) after 4 hours of reperfusion.
Discussion of modifications for evaluating cardiac function and remodeling by altering reperfusion duration.

Main Results:

The described rat AMI model effectively mimics pathological cardiac remodeling and LV dysfunction seen in human heart failure.
The protocol allows for quantitative assessment of myocardial damage (infarct size and AAR).
The model is adaptable for studying the long-term consequences of MI and testing interventions.

Conclusions:

The rat AMI model is a valuable tool for biomedical research into the pathophysiology of heart failure.
This model facilitates the study of intracellular signaling pathways involved in cardiac remodeling post-MI.
The AMI rat model aids in the preclinical assessment of novel therapeutic strategies for heart failure treatment.