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Published on: May 28, 2019
Hydrogen sulfide-mediated myocardial pre- and post-conditioning
Benjamin L Predmore1, David J Lefer
1Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Insights
Hydrogen sulfide protects the heart from damage during heart attacks. This molecule is a potent agent for pre-conditioning and post-conditioning, reducing cell death in myocardial infarction.
Area of Science:
- Cardiology
- Biochemistry
- Molecular Biology
Background:
- Coronary artery disease (CAD) is a leading cause of death globally.
- Acute myocardial infarction (heart attack) results from CAD and causes significant myocardial cell death.
- Myocardial pre- and post-conditioning are strategies to reduce cell death, but their mechanisms require further elucidation.
Purpose of the Study:
- To explore the cardioprotective signaling pathways of hydrogen sulfide.
- To investigate hydrogen sulfide's role as a pre- and post-conditioning agent in myocardial infarction.
Main Methods:
- Review of existing literature on hydrogen sulfide and cardioprotection.
- Analysis of signaling pathways implicated in hydrogen sulfide-mediated myocardial protection.
Main Results:
- Hydrogen sulfide is identified as a potent signaling molecule with significant cardioprotective effects.
- Hydrogen sulfide demonstrates high efficacy as both a pre-conditioning and post-conditioning agent.
Conclusions:
- Hydrogen sulfide offers a promising therapeutic strategy for reducing myocardial cell death in acute myocardial infarction.
- Further research into hydrogen sulfide signaling pathways can optimize its clinical application in treating heart attack consequences.
Abstract:
Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article.
