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Updated: Jun 3, 2026
Extraction and Analysis of Taiwanese Green Propolis
Published on: January 7, 2019
Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats
Chwan-Li Shen1, Christina Samathanam, Owatha L Tatum
1Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, Lubbock, TX 79430-9097, USA. leslie.shen@ttuhsc.edu
Objective:
Green tea proposes anti-inflammatory properties which may attenuate chronic inflammation-induced fibrosis of vessels. This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation.
Treatments:
Forty 3-month-old female rats were assigned to a 2 (placebo vs. lipopolysaccharide, administration) × 2 (no GTP vs. 0.5% GTP in drinking water) factorial design for 12 weeks.
Methods:
Masson's trichrome staining evaluated myocardial fibrosis in coronary vessels and surrounding myocardium. Whole blood specimens were counted for differentials. Spleen tumor necrosis factor-α (TNF-α) mRNA expression was determined by real-time RT-PCR. Data were analyzed by two-way analysis of variance (ANOVA) followed by mean separation procedures.
Results:
After 12 weeks, lipopolysaccharide administration induced myocardial fibrosis in vessels and surrounding myocardium, spleen TNF-α mRNA expression, and leukocytes, while GTP supplementation in drinking water significantly averted such observation.
Conclusions:
GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses.
