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Updated: Jun 3, 2026

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
Published on: January 7, 2019
HSV Vectors for Gene Therapy
1Department of Microbiology and Immunology, Reed Neurological Research Centre, UCLA Medical Centre, Los Angeles, CA.
Abstract:
A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are 1 Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1); 2 Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2), and 3. Nonreplicating HSV recombinants can establish a latent infection efficiently (3).
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