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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Related Experiment Video

Updated: Jun 3, 2026

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Antigen uptake by dendritic cells.

C Caux¹, B Dubois

¹Laboratory for Immunological Research, Schering- Plough, Dardilly, France.

Methods in Molecular Medicine

|March 5, 2011

Summary

This summary is machine-generated.

Newly generated dendritic cells (DCs) migrate from bone marrow to tissues, mature during migration, and prime T-cell responses in lymph nodes. Tissue DCs capture antigens during injury and travel via lymph to initiate adaptive immunity.

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Last Updated: Jun 3, 2026

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

Immunology
Cell Biology

Background:

Dendritic cells (DCs) are crucial immune cells originating in the bone marrow.
These cells circulate to non-lymphoid tissues and migrate to lymph nodes upon activation.

Purpose of the Study:

To elucidate the migratory pathway and maturation process of dendritic cells.
To understand the role of tissue-resident DCs in initiating adaptive immune responses.

Main Methods:

The study describes the life cycle of dendritic cells based on established immunological principles.
Observation of dendritic cell migration from bone marrow to tissues and lymph nodes.

Main Results:

Newly generated DCs migrate from bone marrow to peripheral tissues via the bloodstream.
Upon antigen capture during injury, tissue DCs mature and migrate through afferent lymph to lymph nodes.
Mature DCs present antigens in lymph nodes, initiating T-cell responses.

Conclusions:

Dendritic cell migration and maturation are essential for effective antigen presentation and T-cell priming.
Tissue DCs play a pivotal role in bridging innate and adaptive immunity.
The study outlines the functional life cycle of dendritic cells in immune surveillance and response.