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Updated: Jun 3, 2026

Electrophoretic Separation of Proteins

Electrophoretic Separation of Proteins

Published on: June 12, 2008

Serum protein electrophoresis.

¹Division of Laboratory Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.

Methods in Molecular Medicine

|March 5, 2011

Summary

Serum protein electrophoresis (SPE) detects monoclonal proteins, which signal B-cell disorders. Early identification of these proteins is crucial for timely treatment and improved patient outcomes.

Area of Science:

Clinical chemistry
Immunology
Hematology

Background:

Serum protein electrophoresis (SPE) is a long-standing clinical laboratory technique.
Monoclonal paraproteins in serum indicate B-cell dyscrasias.

Purpose of the Study:

To elucidate and quantitate monoclonal paraproteins using SPE.
To highlight the clinical significance of identifying B-cell dyscrasias.

Main Methods:

Utilizes serum protein electrophoresis (SPE).
Focuses on the detection and quantification of monoclonal paraproteins.

Main Results:

SPE effectively identifies monoclonal paraproteins.
These proteins serve as key indicators for B-cell dyscrasias.

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Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum

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Published on: April 13, 2018

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Last Updated: Jun 3, 2026

Electrophoretic Separation of Proteins

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Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum

Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum

Published on: April 13, 2018

Conclusions:

SPE is a vital tool for diagnosing B-cell dyscrasias.
Untreated B-cell dyscrasias associated with monoclonal paraproteins can be life-threatening.