Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery

Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery

Published on: March 8, 2024

DNA-Based Immunization of Neonatal Mice.

C L Brazolot Millan¹, H L Davis

¹Loeb Research Hospital, Ottawa Civic Hospital, Ottawa, Canada.

Methods in Molecular Medicine

|March 5, 2011

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intramuscular and intradermal injection of DNA vaccines in mice and primates.

Methods in molecular medicine·2011

Same author

Intramuscular injection of DNA vaccines in fish.

Methods in molecular medicine·2011

Same author

Immunostimulatory CpG motifs and DNA vaccines.

Methods in molecular medicine·2011

Same author

Mucosal immunization with DNA vaccines.

Methods in molecular medicine·2011

Same author

CPG 7909 adjuvant plus hepatitis B virus vaccination in HIV-infected adults achieves long-term seroprotection for up to 5 years.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2008

Same author

Quantification of oligodeoxynucleotides in human plasma with a novel hybridization assay offers greatly enhanced sensitivity over capillary gel electrophoresis.

Oligonucleotides·2005

Same journal

Erratum to: Immunotherapeutic Approach to Cancer with Cutaneous DNA Vaccination.

Methods in molecular medicine·2015

Same journal

Methods for cancer gene therapy using tumor suppressor genes.

Methods in molecular medicine·2014

Same journal

Suppression of the human carcinoma phenotype by an antioncogene ribozyme.

Methods in molecular medicine·2014

Same journal

Methods for the use of stromal cells for therapeutic gene therapy.

Methods in molecular medicine·2014

Same journal

Methods for adenovirus-mediated gene transfer to synovium in vivo.

Methods in molecular medicine·2014

Same journal

Methods for gene transfer to synovium.

Methods in molecular medicine·2014

See all related articles

Neonatal immunization is explored to determine immune system maturity and optimal timing. Research addresses whether infants can be immunized despite maternal antibodies, preventing tolerance induction.

Area of Science:

Immunology
Neonatal Research
Vaccinology

Background:

The neonatal immune system's capacity to respond to vaccines is a critical consideration for early protection.
Passive immunity from maternal antibodies can interfere with active immunization responses in newborns.
Understanding neonatal immune responses is crucial for developing effective infant vaccination strategies.

Purpose of the Study:

To assess the maturational status of the neonatal immune system for effective immunization.
To determine the earliest feasible age for neonatal vaccination.
To investigate the potential for inducing immune tolerance versus protective immunity in neonates.
To evaluate the impact of maternal antibodies on the efficacy of neonatal immunization.

Main Methods:

More Related Videos

Intravenous Injections in Neonatal Mice

Intravenous Injections in Neonatal Mice

Published on: November 11, 2014

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

Published on: September 15, 2014

Related Experiment Videos

Last Updated: Jun 3, 2026

Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery

Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery

Published on: March 8, 2024

Intravenous Injections in Neonatal Mice

Intravenous Injections in Neonatal Mice

Published on: November 11, 2014

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

Published on: September 15, 2014

Review of existing literature on neonatal immunology and vaccine responses.
Analysis of immunological assays assessing neonatal immune cell function.
Examination of animal models and human infant studies concerning vaccination timing and maternal antibody interference.

Main Results:

The neonatal immune system exhibits varying degrees of maturity, influencing vaccine responsiveness.
Evidence suggests specific windows for effective immunization, even in the presence of maternal antibodies.
Tolerance induction is a potential concern but can be overcome with appropriate vaccine strategies.

Conclusions:

Neonatal immunization is feasible, but optimal timing and vaccine design are critical.
Strategies exist to overcome maternal antibody interference, enabling effective neonatal vaccination.
Further research is needed to refine neonatal immunization schedules and vaccine platforms for maximal protection.