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Updated: Jun 3, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
Published on: April 11, 2019
DNA vaccination : tolerance and autoimmunity
1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT.
Abstract:
Infectious diseases result in significant morbidity and mortality worldwide. Preventing these infections is both a public health priority and the primary goal of vaccine research. The discovery that cell-mediated and/or humoral immune responses against viruses, parasites, bacteria and tumor antigens can be induced by antigen-encoding DNA plasmids is revolutionizing the vaccine development field (1-3). DNA vaccines (also known as plasmid DNA or nucleic acid vaccines) have been proven to successfully prevent infection in a variety of animal models, and are currently undergoing clinical trials in humans for the prevention of a variety of infections, including HIV (1,4,5).
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