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Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR (RS-PCR)

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Published on: November 4, 2016

Restriction Fragment End Labeling Analysis: High-Resolution Genomic Typing of Streptococcus pneumoniae Isolates.

P W Hermans¹, M Sluijter, A van Belkum

¹Department of Paediatrics, Erasmus University Medical Center Rotterdam, Rotterdamdam, The Netherlands.

Methods in Molecular Medicine

|March 5, 2011

Summary

Streptococcus pneumoniae causes significant illness and death, particularly in vulnerable groups. Nasopharyngeal colonization by pneumococcus increases the risk of developing acute otitis media in children.

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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

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Last Updated: Jun 3, 2026

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR (RS-PCR)

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Published on: November 4, 2016

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

Area of Science:

Microbiology
Pediatrics
Epidemiology

Background:

Streptococcus pneumoniae (pneumococcus) is a major bacterial pathogen responsible for considerable morbidity and mortality.
It frequently colonizes the nasopharynx, especially in young children, serving as a reservoir for transmission.
Pneumococcal colonization is a recognized risk factor for subsequent infections.

Purpose of the Study:

To highlight Streptococcus pneumoniae as a leading cause of illness and death.
To emphasize the role of pneumococcal nasopharyngeal colonization in disease pathogenesis.
To underscore the association between pneumococcal colonization and acute otitis media in children.

Main Methods:

Literature review of studies on Streptococcus pneumoniae epidemiology and pathogenesis.
Analysis of data linking nasopharyngeal colonization to clinical outcomes.
Synthesis of evidence regarding risk factors for pneumococcal infections.

Main Results:

Streptococcus pneumoniae is identified as a primary cause of bacterial illness and mortality globally.
Pneumococcal carriage is common in the nasopharynx, particularly among pediatric populations.
Children with S. pneumoniae colonization exhibit a higher incidence of acute otitis media.

Conclusions:

Streptococcus pneumoniae poses a significant public health threat, especially to vulnerable populations.
Nasopharyngeal colonization by pneumococcus is a critical factor in the development of otitis media.
Understanding colonization dynamics is essential for preventing pneumococcal diseases.