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HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?
Thiago Gomes Heck1, Cinthia Maria Schöler, Paulo I Homem de Bittencourt
1Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. gomesheck@yahoo.com
Cell Biochemistry and Function
|March 5, 2011
Summary
Exercise-induced extracellular heat shock proteins 70 (eHSP70) may contribute to fatigue. Increased eHSP70 levels during exercise could signal danger from the immune system to the central nervous system.
Area of Science:
- Integrative physiology
- Neuroimmunology
- Exercise physiology
Background:
- The immune system and central nervous system closely interact to modulate behavior.
- Heat shock proteins 70 (HSP70s) are highly conserved and expressed during exercise.
- Extracellular HSP70 (eHSP70) may act as an immunomodulatory agent during physical exertion.
Purpose of the Study:
- To investigate the potential role of HSP70s in exercise-induced fatigue.
- To explore the release and function of extracellular HSP70 (eHSP70) during exercise.
- To understand eHSP70's contribution to the fatigue sensation and immune signaling.
Main Methods:
- Analysis of circulating eHSP70 levels during exercise.
- Measurement of eHSP70 release from lymphocytes during high-load exercise.
- Exploration of eHSP70's interaction with neural cells.
Main Results:
- Increased plasma eHSP70 levels were observed during exercise.
- Significant release of eHSP70 from lymphocytes occurred during high-load exercise.
- eHSP70 may act as a danger signal, influencing fatigue.
Conclusions:
- Extracellular HSP70 (eHSP70) released during exercise may contribute to fatigue sensation.
- eHSP70 acts as an immunomodulatory mechanism, signaling danger to the nervous system.
- Further research is warranted to elucidate the precise mechanisms of eHSP70 in exercise physiology.
