Related Experiment Video
Updated: Jun 3, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
[Hormonal treatment effectivity in hyperandrogenic syndrome]
J Visnovský1, K Biringer, I Svecová
1Gynekologicko-pôrodnicka klinika JLF UK, Martin, Slovensko. visnovsky@jfmed.uniba.sk
Objective:
To evaluate effectiveness of hormonal treatment of hyperandrogenic syndrome (HAS).
Design:
Prospective randomized study.
Setting:
Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
Methods:
We assessed effect of one-year-long hormonal treatment on menstrual cycles (MC), clinical signs of HAS, and ultrasound finding (USG) in 90 patients with HAS. Patients were divided into three groups with 30 females: A--35 microg ethinylestradiol (EE) with 2.0 mg cyproterone acetate/day; B--30 microg EE with 2.0 mg dienogest/day; C--30 microg EE with 3.0 mg drospirenone/day.
Results:
It was achieved a positive effect on MC regularity in every group during the first six months of treatment (p < 0.001). Signs of hirsutism, virilization, and USG finding were significantly better in group A.
Conclusion:
The most effective hormonal treatment in our study was the combination of 35 microg EE with 2.0 mg cyproterone acetate/day.
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