Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Hormonal Regulation

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

Hormonal Control of the Ovarian Cycle

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.

Target Cell Response to Hormones

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cytological versus histological results in ASCUS cervical dysplasia - a retrospective study.

Ceska gynekologie·2026

Same author

Circulating HPV DNA in patients with cervical precancerous lesions and cervical cancer.

Ceska gynekologie·2021

Same author

Factors affecting the uterine sarcomas developement and possibilities of their clinical diagnosis.

Ceska gynekologie·2019

Same author

Potential of survivin for treatment of gynaecological tumour diseases.

Ceska gynekologie·2019

Same author

The influence of food restriction on the small bowel: Does intensive short‑term food restriction lead to weight loss?

Bratislavske lekarske listy·2017

Same author

[Coeliac disease as a possible cause of some gynecological and obstetric abnormalities].

Ceska gynekologie·2016

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

[Hormonal treatment effectivity in hyperandrogenic syndrome].

J Visnovský¹, K Biringer, I Svecová

¹Gynekologicko-pôrodnicka klinika JLF UK, Martin, Slovensko. visnovsky@jfmed.uniba.sk

Ceska Gynekologie

|March 8, 2011

Summary

The most effective hormonal treatment for hyperandrogenism (HAS) was ethinylestradiol with cyproterone acetate. This combination improved menstrual regularity and clinical signs of HAS.

More Related Videos

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

Published on: July 5, 2024

Related Experiment Videos

Last Updated: Jun 3, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

Published on: July 5, 2024

Area of Science:

Gynecology
Endocrinology
Reproductive Medicine

Context:

Hyperandrogenic syndrome (HAS) affects numerous women of reproductive age.
Effective management of HAS is crucial for improving quality of life and preventing long-term health complications.
Hormonal therapies are a cornerstone in treating HAS, but optimal regimens require further investigation.

Purpose:

To compare the effectiveness of three different combined oral contraceptives in managing HAS.
To evaluate the impact of hormonal treatment on menstrual cycles, clinical hyperandrogenic signs, and ultrasound findings.

Summary:

A prospective randomized study involving 90 patients with HAS compared three hormonal treatments over one year.
Group A received ethinylestradiol (EE) with cyproterone acetate, Group B received EE with dienogest, and Group C received EE with drospirenone.
All treatments improved menstrual cycle regularity within six months. However, ethinylestradiol with cyproterone acetate showed superior results in reducing hirsutism, virilization, and improving ultrasound findings.

Impact:

The findings suggest that a specific hormonal regimen (35 mcg EE with 2.0 mg cyproterone acetate) is the most effective for managing HAS.
This provides valuable evidence for clinicians in selecting optimal treatment strategies for patients with HAS.
Improved management of HAS can lead to better reproductive health outcomes and reduced androgenic side effects.