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Related Concept Videos

Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

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Related Experiment Video

Updated: Jun 3, 2026

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Published on: February 19, 2020

Critical illness myopathy.

Salima Moez Meherali1, Yasmin Parpio, Tazeen Saeed Ali

  • 1School of Nursing, Department of Community Health Sciences, The Aga Khan University, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|March 8, 2011
PubMed
Summary

Critical illness myopathy (CIM) is a neuromuscular disorder causing weakness in intensive care patients. Early recognition and awareness are crucial for managing this condition in critical care settings.

Area of Science:

  • Neurology
  • Intensive Care Medicine
  • Physiology

Background:

  • Critical illness myopathy (CIM) is a neuromuscular disorder characterized by muscle weakness and dysfunction in critically ill patients.
  • Its exact causes remain unknown, but it is often linked to systemic inflammatory response syndrome in the Intensive Care Unit (ICU).
  • Diagnosis typically involves electrophysiologic testing or muscle/nerve biopsy.

Observation:

  • This case report details a 60-year-old male with Chronic Obstructive Lung Disease (COPD) admitted to the ICU.
  • The report focuses on the clinical features, diagnosis, and treatment of CIM in this specific patient.
  • The patient developed CIM after a period of intensive care.

Findings:

  • CIM presents as widespread muscle weakness and neurological impairment in ICU patients.

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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
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Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties
08:27

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Published on: February 19, 2020

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

  • The condition can develop even after a short stay in the ICU.
  • This case highlights the clinical presentation and management challenges of CIM.
  • Implications:

    • Healthcare professionals in critical care units must maintain a high index of suspicion for CIM in all ICU patients.
    • Awareness of CIM is essential for timely diagnosis and appropriate management strategies.
    • Understanding CIM's clinical features can improve patient outcomes in intensive care settings.