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Updated: Jun 3, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

Published on: December 8, 2023

Labdane diterpenoids from Leonurus sibiricus.

Hankui Wu¹, Frank R Fronczek, Daneel Ferreira

¹Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA.

Journal of Natural Products

|March 8, 2011

Summary

This summary is machine-generated.

Researchers isolated six new labdane diterpenoids from *Leonurus sibiricus* leaves. X-ray crystallography confirmed the structures of four compounds, revealing one as an isolation artifact.

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Last Updated: Jun 3, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

Published on: December 8, 2023

Area of Science:

Natural Product Chemistry
Organic Chemistry
Phytochemistry

Background:

*Leonurus sibiricus* is a plant species known for its traditional medicinal uses.
Diterpenoids are a class of natural products with diverse biological activities.
The chemical constituents of *Leonurus sibiricus* are not fully elucidated.

Purpose of the Study:

To isolate and characterize new labdane diterpenoids from *Leonurus sibiricus* leaves.
To determine the absolute configurations of the isolated compounds.
To identify any artifacts formed during the isolation process.

Main Methods:

Extraction and isolation of compounds from *Leonurus sibiricus* leaves.
Spectroscopic analysis (NMR, MS) for structural elucidation.
X-ray crystallographic analysis for absolute configuration determination.

Main Results:

Six new labdane diterpenoids, preleosibirone A (1), 13-epi-preleosibirone A (2), isopreleosibirone A (3), leosibirone A (4), leosibirone B (5), and 15-epi-leosibirone B (6), were isolated.
The absolute configurations of compounds 1, 2, 5, and 6 were established via X-ray crystallography.
Leosibirone A (4) was identified as an artifact of the isolation procedure.

Conclusions:

The study successfully identified novel labdane diterpenoids from *Leonurus sibiricus*.
The structural and stereochemical characterization provides valuable data for natural product chemistry.
Understanding isolation artifacts is crucial for accurate natural product research.