Related Experiment Video
Updated: Jun 3, 2026
10:23
A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
The peptide AF-16 decreases high interstitial fluid pressure in solid tumors
Mohamed Al-Olama1, Annacarin Wallgren, Bengt Andersson
1Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Acta Oncologica (Stockholm, Sweden)
|March 8, 2011
Summary
The peptide AF-16 effectively reduces high interstitial fluid pressure (IFP) in solid tumors. This temporary pressure decrease may enhance drug delivery and therapeutic outcomes.
Area of Science:
- Oncology
- Pharmacology
- Biophysics
Background:
- High interstitial fluid pressure (IFP) in solid tumors impedes nutrient, oxygen, and drug delivery.
- Understanding mechanisms to reduce IFP is crucial for improving cancer therapy.
Purpose of the Study:
- To evaluate the efficacy of the peptide AF-16 in reducing IFP in rat mammary tumors.
- To assess the impact of AF-16 administration route on IFP reduction.
Main Methods:
- Investigated AF-16's effect on IFP in chemically induced and transplantable rat mammary tumors.
- Administered AF-16 via intratumoral, intranasal, and intravenous routes.
- Measured IFP using a miniature fiber optic device.
Main Results:
- AF-16 significantly reduced IFP in both slow-growing and rapidly progressing tumors.
- IFP reduction was observed with local and systemic AF-16 administration.
- The effect was maximal at 90 minutes, lasted over 3 hours, and was reversible within 24 hours.
Conclusions:
- AF-16 demonstrates a transient and reversible ability to lower high IFP in solid tumors.
- This IFP reduction holds potential for improving the efficacy of cancer treatments.
