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Updated: Jun 3, 2026

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
Emerging roles of ROS/RNS in muscle function and fatigue
Håkan Westerblad1, David G Allen
1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. hakan.westerblad@ki.se
Abstract:
Reactive oxygen and nitrogen species (ROS/RNS) are involved in numerous aspects of cellular signaling. Classically ROS/RNS have been associated with cellular dysfunction and disease, but it is now clear that they are also of integral importance under normal conditions. In this review, we discuss ROS/RNS effects in skeletal muscle, with special focus on changes in contractile function. The review deals with the tentative roles of ROS/RNS for acute changes that can occur during strenuous exercise resulting in muscle fatigue, for the recovery from fatigue, and for the effects of training/overtraining. We also discuss two groups of inherited diseases; muscle dystrophies, where recent data suggest that ROS/RNS may be of unexpectedly large importance, and mitochondrial myopathies, where the role of ROS seems more limited than originally thought.
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