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Related Experiment Video

Updated: Jun 3, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
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Initial experience using a hyaluronate-iodine complex for wound healing.

Robert A Brenes1, Michael S Ajemian, Shady H Macaron

  • 1Saint Mary's Hospital, The Stanley J. Dudrick Department of Surgery, Waterbury, Connecticut 06706, USA. robert.brenes@stmh.org

The American Surgeon
|March 8, 2011
PubMed
Summary
This summary is machine-generated.

Hyaluronate-iodine complex shows promise as a wound healing agent, aiding in the successful closure of 14 wounds in a pilot study. Its antiadhesive and antimicrobial properties create an optimal healing environment.

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Area of Science:

  • Wound Healing
  • Biomaterials
  • Antimicrobial Agents

Background:

  • Hyaluronate-iodine complex is an approved wound healing adjuvant in the European Union.
  • The need for effective wound healing agents is critical in clinical practice.
  • Understanding the efficacy of existing adjuvants is essential for optimizing patient care.

Purpose of the Study:

  • To validate the efficacy of hyaluronate-iodine as a wound healing agent.
  • To assess the clinical performance of hyaluronate-iodine in a prospective patient cohort.
  • To evaluate the safety and tolerability of hyaluronate-iodine treatment.

Main Methods:

  • Prospective study involving 14 patients (19 wounds) from hospital, outpatient, and wound healing center settings.
  • Application of hyaluronate-iodine soaked gauze daily or every other day based on wound exudate.
  • Weekly wound measurement and digital photography documentation; standard surgical debridement as needed.

Main Results:

  • Fourteen out of nineteen wounds achieved complete healing, with a mean healing time of 18.1 ± 15.1 weeks.
  • Treatment was completed by 10 patients; four patients discontinued due to pain, logistical issues, or loss to follow-up.
  • Hyaluronate-iodine demonstrated effectiveness across all wound types treated in this pilot study.

Conclusions:

  • Hyaluronate-iodine is a beneficial agent for promoting wound healing.
  • The antiadhesive and antimicrobial properties contribute to a favorable wound healing environment.
  • No apparent detrimental effects were observed during this pilot investigation.