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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
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Pediatric surgery and the human microbiome

Erica M Carlisle1, Michael J Morowitz

  • 1Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA.

Journal of Pediatric Surgery
|March 8, 2011
PubMed

Insights

Recent advances allow studying the pediatric microbiota

Area of Science:

  • Microbiome research and its application in pediatrics.

Background:

  • The intestinal microbiota's role in adult diseases is established, but its impact on pediatric surgical conditions is understudied.
  • Novel culture-independent techniques enable detailed analysis of microbial communities.

Purpose of the Study:

  • To review the pediatric microbiota's unique characteristics and manipulation strategies.
  • To examine the role of gut microbes in necrotizing enterocolitis, obesity, and inflammatory bowel disease relevant to pediatric surgery.

Main Methods:

  • Utilizing culture-independent approaches to profile microbes in clinical specimens.
  • Reviewing existing literature on pediatric microbiota and surgical diseases.

Main Results:

  • Highlighting unique features of the pediatric microbiota.
  • Detailing microbial contributions to necrotizing enterocolitis, obesity, and inflammatory bowel disease.

Conclusions:

  • Pediatric microbiota research offers potential for improved surgical outcomes in infants and children.
  • Future research will likely enhance understanding and treatment of pediatric surgical conditions.

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