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Related Experiment Video

Updated: Jun 3, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Nutritional support for critically ill patients: does duration correlate with mortality?

Alvaro A C Morais¹, Joel Faintuch², Eliana B Caser³

¹Nutritional Support Service, EMESCAM Medical School, Vitoria, ES, Brazil.

Journal of Critical Care

|March 8, 2011

Summary

Long-term nutritional support (NS) in intensive care units (ICUs) is linked to increased mortality. Patients receiving NS for over 18 days had a significantly higher mortality rate compared to those with shorter durations.

Related Experiment Videos

Last Updated: Jun 3, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Area of Science:

Critical Care Medicine
Clinical Nutrition
Outcomes Research

Background:

Limited research exists on the correlation between long-term nutritional support (NS) and patient outcomes in the intensive care unit (ICU).
Understanding the impact of prolonged NS duration is crucial for optimizing patient care and survival rates in critical illness.

Purpose of the Study:

To analyze the duration of enteral and/or parenteral nutrition in critically ill patients.
To investigate the relationship between nutritional support duration, illness severity, and hospital mortality.

Main Methods:

A retrospective analysis of 100 critically ill patients was conducted.
Data collected included patient demographics, diagnosis, Acute Physiologic and Chronic Health Evaluation II (APACHE II) scores, mechanical ventilation status, and nutritional support modality and duration.
Propensity matching was used to control for confounding variables such as age, APACHE II, Glasgow scale, and mechanical ventilation.

Main Results:

Patients receiving nutritional support for 18 days or less (mean 4.3 days) had a favorable survival rate (7.7% mortality).
Conversely, patients receiving nutritional support for longer periods (mean 48.5 days) experienced substantially increased mortality (50.0%).
This association between prolonged NS (>18 days) and higher mortality persisted even after propensity matching for key risk factors (6.3% vs. 50.0%, P = .04).

Conclusions:

Nutritional support exceeding 18 days in the ICU is significantly associated with increased hospital mortality.
This finding suggests that prolonged inability to achieve oral alimentation may serve as a marker for higher mortality risk in critically ill patients.
The results highlight the importance of considering the duration of nutritional support in risk stratification and management strategies for ICU patients.