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Related Concept Videos

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Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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G-protein Coupled Receptors01:21

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Updated: Jun 3, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

GABAB receptor modulation of synaptic function.

Jason R Chalifoux1, Adam G Carter

  • 1Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, United States.

Current Opinion in Neurobiology
|March 8, 2011
PubMed
Summary
This summary is machine-generated.

Metabotropic GABAB receptors modulate synaptic transmission by reducing presynaptic glutamate release and postsynaptic calcium influx. These findings reveal GABAB receptors

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Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
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Related Experiment Videos

Last Updated: Jun 3, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
11:57

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

Published on: March 28, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Synaptic Plasticity

Background:

  • Neuromodulators significantly influence neurotransmitter release and detection.
  • Metabotropic GABAB receptors play a critical role in regulating neuronal communication.

Purpose of the Study:

  • To elucidate the mechanisms by which GABAB receptors modulate synaptic transmission.
  • To highlight recent advances in understanding GABAB receptor function at synapses.

Main Methods:

  • Investigated GABAB receptor signaling pathways.
  • Examined effects on presynaptic neurotransmitter release.
  • Analyzed postsynaptic responses, including calcium permeability.

Main Results:

  • GABAB receptors inhibit multivesicular release, decreasing synaptic glutamate.
  • GABAB receptors reduce NMDA receptor Ca2+ permeability, lowering postsynaptic Ca2+ signals.
  • Demonstrated GABAB receptors' dual role in presynaptic and postsynaptic modulation.

Conclusions:

  • GABAB receptors are crucial regulators of synaptic transmission.
  • New insights into GABAB receptor function open avenues for studying brain dynamics.
  • Further research is needed on the spatiotemporal aspects of synaptic modulation.