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Updated: Jun 3, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study
Qianyi Chen1, Vashti C Bryant, Hernando Lopez
1Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, United States.
None:
The quinoxaline core is considered a privileged scaffold as it is found in a variety of biologically relevant molecules. Here we report the synthesis of a quinoxalin-6-amine library, screening against a panel of cancer cell lines and a structure-activity relationship (SAR). This resulted in the identification of a bisfuranylquinoxalineurea analog (7c) that has low micromolar potency against the panel of cancer cell lines. We also show that cells treated with quinoxalineurea 7c results in caspase 3/7 activation, PARP cleavage and Mcl-1 dependent apoptosis.
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