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Updated: Jun 3, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
Kinases and phosphatases in the mammalian circadian clock
1Laboratory of Chronobiology, Charité Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.
Abstract:
Posttranslational modifications of circadian oscillator components are crucial for the generation of circadian rhythms. Among those phosphorylation plays key roles ranging from regulating degradation, complex formation, subcellular localization and activity. Although most of the known clock proteins are phosphoproteins in vivo, a comprehensive view about the regulation of clock protein phosphorylation is still missing. Here, we review our current knowledge about the role of clock protein phosphorylation and its regulation by kinases and phosphatases in eukaryotes with a major focus on the mammalian circadian clock.
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