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Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Probiotics and neonatal necrotizing enterocolitis.

Erika C Claud1

  • 1Department of Pediatrics, Section of Neonatology, The University of Chicago, IL 60637, USA. eclaud@peds.bsd.uchicago.edu

Anaerobe
|March 8, 2011
PubMed
Summary
This summary is machine-generated.

Probiotics may benefit preterm infants with necrotizing enterocolitis (NEC), but their effects on the developing gut microbiome and safety require further investigation. Understanding microbial colonization is key to NEC prevention in vulnerable infants.

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Published on: July 28, 2022

Area of Science:

  • Neonatology
  • Microbiology
  • Gastroenterology

Background:

  • Necrotizing enterocolitis (NEC) is a significant concern in preterm infants.
  • Probiotics show potential benefits for NEC, but safety and efficacy are debated.
  • The developing gut microbiome plays a critical role in infant health.

Purpose of the Study:

  • To examine the impact of probiotics on the preterm infant gut microbiome.
  • To investigate the safety of probiotics in clinical trials for NEC.
  • To understand microbial colonization patterns in the neonatal intensive care unit (NICU) environment.

Main Methods:

  • Review of existing clinical trials on probiotics for NEC.
  • Analysis of studies on gut microbial colonization in preterm infants.
  • Assessment of factors influencing the preterm gut microbiome, including NICU interventions.

Main Results:

  • Probiotics demonstrate potential clinical benefits in reducing NEC incidence.
  • Concerns regarding probiotic safety and long-term effects persist.
  • The preterm gut microbiome is highly susceptible to environmental and iatrogenic influences.

Conclusions:

  • Further research is needed to clarify probiotic efficacy and safety in preterm neonates.
  • Understanding the complex interplay between the microbiome and NEC is crucial.
  • Optimizing microbial colonization may be a strategy for NEC prevention.