Related Experiment Video
Updated: Jun 3, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
Published on: February 7, 2025
[Neurobiological consequences of child sexual abuse: a systematic review]
Noemí Pereda1, David Gallardo-Pujol
1Facultat de Psicologia, Universitat de Barcelona, Barcelona, España. npereda@ub.edu
Insights
Child sexual abuse can cause lasting neurobiological changes, impacting the hypothalamus-pituitary-adrenal axis. This review details these effects, emphasizing the need for targeted interventions for affected children.
Area of Science:
- Neuroscience
- Developmental Psychology
- Public Health
Background:
- Child maltreatment and sexual abuse can induce critical, long-lasting neurobiological changes.
- These changes often impact the hypothalamus-pituitary-adrenal axis response during sensitive developmental periods.
Purpose of the Study:
- To conduct an updated review of the primary neurobiological consequences of child sexual abuse.
- To consolidate current research on the lasting effects of childhood sexual victimization.
Main Methods:
- Systematic literature search of Medline, Scopus, and Web of Science for articles published between January 1999 and January 2010.
- Inclusion of studies in English or Spanish focusing on neurobiological outcomes of child sexual abuse.
- Examination of reference lists from relevant published articles on childhood sexual victimization.
Main Results:
- Included 34 studies detailing various neurobiological consequences.
- Identified neuroendocrine, structural, functional, and neuropsychological effects.
- These consequences affect a significant number of child sexual abuse victims.
Conclusions:
- Child maltreatment and sexual abuse represent critical public health issues with widespread neurobiological impacts.
- Recognizing these multiple effects is essential for developing effective intervention and treatment programs.
- Further research and clinical attention are needed to address the long-term health implications for victims.
Objective:
The results of several studies suggest that there is a critical timeframe during development in which experiences of maltreatment and sexual abuse may lead to permanent or long-lasting neurobiological changes that particularly affect the hypothalamus-pituitary-adrenal axis response. The aim of the present study was to provide an updated review on the main neurobiological consequences of child sexual abuse.
Methods:
We selected articles published between January 1999 and January 2010 in English or Spanish that focused on the neurobiological consequences of child sexual abuse available through Medline, Scopus and Web of Science. We also examined the references in published articles on the consequences of sexual victimization in childhood.
Results:
In this review we included 34 studies on neurobiological consequences, indicating different kinds of effects, namely: neuroendocrine, structural, functional and neuropsychological consequences, which affect a large number of victims.
Conclusions:
The existing body of work on the neurobiological consequences of maltreatment shows the need to consider maltreatment and child sexual abuse as health problems that affect different areas of victims' lives, which would in turn favor the development of intervention and treatment programs that take these multiple effects into account.
Related Concept Videos
Sex Linked Disorders
Sex-linked Disorders
Psychosexual Theory of Development
The Five Stages of Psychosexual Development
Freud's psychosexual...
Amebiasis
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Bullying

