Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Alterations in Muscle Tone lll

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gastrointestinal involvement in dermatomyositis: multicentric retrospective cohort study.

Rheumatology (Oxford, England)·2026

Same author

Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis.

Cell death & disease·2026

Same author

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway.

NAR molecular medicine·2026

Same author

Inflammatory Myopathies.

The New England journal of medicine·2026

Same author

Clinical characteristics and cancer risk of anti-OJ antisynthetase syndrome: A cohort comparative study and a systematic literature review.

Autoimmunity reviews·2026

Same author

Standardized Interoperable Data Collection for Myositis Research: Developing Expert Consensus on Common Data Elements for Myositis Outcome Measures.

Arthritis care & research·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Myositis or dystrophy? Traps and pitfalls.

Olivier Benveniste¹, Norma B Romero

¹Université Pierre et Marie Curie, Assistance publique-Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, hôpital Pitié-Salpêtrière, service de médecine interne 1, 75013 Paris cedex 13, France. olivier.benveniste@psl.aphp.fr

Presse Medicale (Paris, France : 1983)

|March 8, 2011

Summary

Distinguishing hereditary myopathies from acquired myositis is crucial, as misdiagnosis can lead to incorrect treatments. This review highlights key differences to avoid diagnostic confusion in adult-onset limb-girdle weakness.

More Related Videos

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Related Experiment Videos

Last Updated: Jun 3, 2026

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

Area of Science:

Neurology
Genetics
Immunology

Background:

Hereditary myopathies can present in adulthood mimicking acquired myositis, particularly with limb-girdle weakness.
Diagnostic challenges arise due to slow progression and painless onset in some inherited myopathies, with exceptions causing confusion.

Observation:

Muscle biopsy findings can be misleading, showing inflammatory infiltrates common in certain dystrophies like dysferlinopathies and facioscapulohumeral dystrophy.
Anti-SRP antibody-positive necrotizing myopathies, though acquired and treatable, may exhibit slow progression and features resembling limb-girdle dystrophies.

Findings:

Misdiagnosis can result in inappropriate immunosuppressant therapy for dystrophies or delayed treatment for acquired myopathies.
Careful differentiation is essential to guide appropriate therapeutic strategies for patients presenting with myopathic symptoms.

Implications:

Accurate diagnosis prevents iatrogenic harm from unnecessary immunosuppression in hereditary conditions.
Timely intervention with immunosuppressants for treatable acquired myopathies is vital for patient outcomes.