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Transcranial direct current stimulation modulates the spinal plasticity induced with patterned electrical

Toshiyuki Fujiwara1, Tetsuya Tsuji, Kaoru Honaga

  • 1Department of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan. tofuji@xc5.so-net.ne.jp

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|March 8, 2011
PubMed
Summary

Patterned sensory electrical stimulation (PES) enhances spinal cord plasticity. However, applying cathodal transcranial direct current stimulation (tDCS) to the motor cortex before PES blocked this plasticity, suggesting cortical modulation.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Spinal Cord Physiology

Background:

  • Patterned sensory electrical stimulation (PES) is known to induce neuroplasticity in spinal reciprocal Ia inhibition.
  • Understanding cortical modulation of spinal plasticity is crucial for therapeutic interventions.

Purpose of the Study:

  • To investigate the role of the motor cortex in modulating spinal plasticity induced by PES.
  • To examine the effects of transcranial direct current stimulation (tDCS) applied to the motor cortex prior to PES.

Main Methods:

  • Seven healthy volunteers underwent PES of the left common peroneal nerve.
  • Transcranial direct current stimulation (tDCS) was applied over the motor cortex (anodal or cathodal) before PES.
  • Soleus H reflex conditioning-test paradigm assessed reciprocal inhibition.

Main Results:

  • PES significantly increased disynaptic reciprocal inhibition from the peroneal nerve to the soleus H reflex.
  • Preceding PES with cathodal tDCS to the motor cortex abolished the increase in reciprocal inhibition.
  • Anodal tDCS effects were not explicitly stated but implied to differ.

Conclusions:

  • Motor cortex stimulation, specifically cathodal tDCS, can modulate PES-induced spinal plasticity in a polarity-dependent manner.
  • These findings suggest a significant role for the motor cortex in regulating spinal cord plasticity.