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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
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Teratogenicity

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Symbiosis00:58

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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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Malaria in pregnancy: what's good for the goose may not be good for the goslings.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
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Antibody-Dependent Neutrophil Phagocytosis of Plasmodium falciparum-Infected Erythrocytes Is Mediated by FcγRIIa.

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Related Experiment Video

Updated: Jun 3, 2026

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
09:57

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Malaria in pregnancy: small babies, big problem.

Alexandra J Umbers1, Elizabeth H Aitken, Stephen J Rogerson

  • 1Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Post Office Royal Melbourne Hospital, Parkville, VIC 3050, Australia.

Trends in Parasitology
|March 8, 2011
PubMed
Summary

Placental malaria can cause fetal growth restriction (FGR) by impairing placental function. This review explores malaria

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Last Updated: Jun 3, 2026

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
09:57

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Fetal Medicine

Background:

  • Placental malaria is a significant global health concern.
  • It is strongly linked to fetal growth restriction (FGR).
  • Understanding the pathogenesis is crucial for intervention.

Purpose of the Study:

  • To review recent discoveries on malaria-induced FGR mechanisms.
  • To discuss the impact on placental function and fetal development.
  • To propose strategies for reducing FGR burden in pregnant women with malaria.

Main Methods:

  • Literature review of recent discoveries.
  • Analysis of host responses and placental changes.
  • Discussion of growth-regulating hormones and long-term offspring health.

Main Results:

  • Placental malaria alters placental structure and function.
  • Host responses contribute to pathogenesis.
  • Offspring are predisposed to hypertension and vascular dysfunction.

Conclusions:

  • Malaria during pregnancy significantly impacts fetal growth via placental insufficiency.
  • Further research is needed to fully elucidate pathogenic mechanisms.
  • Intervention strategies are proposed to mitigate FGR associated with placental malaria.