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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

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Related Experiment Video

Updated: Jun 3, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Is there a relationship between bone and critical illness?

Yaozong Zhang1, Xiaolan Du, Lin Chen

  • 1State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

Medical Hypotheses
|March 8, 2011
PubMed
Summary

Critical illness, despite treatments, has high mortality. This study hypothesizes that bone health significantly impacts critical illness development and patient outcomes, suggesting new research directions.

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Last Updated: Jun 3, 2026

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07:17

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Area of Science:

  • Critical illness research
  • Bone biology
  • Pathogenesis of severe diseases

Background:

  • Critical illness involves complex diseases with high mortality rates.
  • Current treatments for critical illness are insufficient.
  • Potential contributing factors include inflammation, metabolic disturbances, and immune dysfunction.

Purpose of the Study:

  • To investigate the role of bone in the pathogenesis of critical illness.
  • To explore the influence of bone on critical illness outcomes.
  • To test the hypothesis that bone is a key factor in critical illness.

Main Methods:

  • Review of published data on bone's influence on hematopoiesis, immunity, and metabolism.
  • Analysis of internal research findings.
  • Formulation of a hypothesis based on existing and new evidence.

Main Results:

  • Bone influences key physiological processes: hematopoiesis, immunity, and metabolism.
  • Existing data suggests a link between bone and critical illness.
  • Preliminary work supports the hypothesis of bone's significant role.

Conclusions:

  • The bone is hypothesized to play a crucial role in the development and progression of critical illness.
  • Further research into bone's involvement may reveal novel therapeutic targets.
  • Understanding bone's function is essential for improving critical illness outcomes.