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Primary lymphoma arising in skeletal muscle
M A Schwalke1, J V Rodil, M P Vezeridis
1Department of Surgery, Brown University, Providence, RI.
Summary
Lymphoma can rarely originate in the biceps muscle. If a muscle mass is found, consider lymphoma in the differential diagnosis for accurate diagnosis and treatment.
Area of Science:
- Oncology
- Pathology
- Musculoskeletal Neoplasms
Background:
- Lymphoma is a malignancy of lymphocytes, typically affecting lymph nodes.
- Primary muscle lymphoma is exceptionally rare, posing diagnostic challenges.
- Skeletal muscle tumors encompass a range of benign and malignant conditions.
Observation:
- A case of lymphoma arising primarily from the biceps muscle is presented.
- This rare presentation highlights the potential for lymphoma to involve skeletal muscle.
- Differential diagnosis of muscle masses must include uncommon etiologies.
Findings:
- Accurate diagnosis of muscle masses requires biopsy with advanced techniques like electron microscopy and immunohistochemistry.
- Histologic diagnosis of an undifferentiated neoplasm is insufficient for guiding treatment.
- Misdiagnosis can lead to inappropriate radical surgery.
Implications:
- Considering lymphoma in the differential diagnosis of muscle tumors is crucial.
- Appropriate diagnostic workup can prevent unnecessary surgical interventions.
- Timely and accurate diagnosis facilitates access to effective, potentially curative nonsurgical therapies for muscle lymphoma.
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