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Published on: December 1, 2016
Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6)
Nagahiko Yumita1, Yumiko Iwase, Koji Nishi
1Yokohama College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan. n.yumita@hamayaku.ac.jp
Background:
The sonodynamically-induced in vitro and in vivo antitumor effects of mono-l-aspartyl chlorin e6 (NPe6) was investigated.
Materials And Methods:
Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz.
Results:
The rate of ultrasonically-induced damage on isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 μM NPe6. The co-administration of 25 mg/kg NPe6 followed by ultrasonic exposure at 2 MHz suppressed the growth of implanted colon 26 cell tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.
Conclusion:
These in vitro and in vivo results suggest that NPe6 is a potential sensitizer for sonodynamic tumor treatment. The enhancement of cell damage by NPe6 was significantly inhibited by histidine, which may suggest reactive oxygen species plays a primary role in sonodynamically-induced antitumor effect.
