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Updated: Jun 3, 2026
Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Hypoxia-inducible adrenomedullin in colorectal cancer
Mamoru Uemura1, Hirofumi Yamamoto, Ichiro Takemasa
1Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan. hyamamoto@gesurg.med.osaka-u.ac.jp
Background:
Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia.
Patients And Methods:
To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n = 222), and quantitative reverse-transcriptase polymerase chain reaction (n = 151).
Results:
ADM was a novel independent prognostic factor for CRC (p = 0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p < 0.0001) and vascular endothelial growth factor (p < 0.0001) in vivo.
Conclusion:
ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.
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