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Intercellular calcium waves in glial cells with bistable dynamics.

Fang Wei¹, Jianwei Shuai

¹Department of Physics and Institute of Theoretical Physics and Astrophysics, Xiamen University, Xiamen 361005, People's Republic of China.

Physical Biology

|March 8, 2011

Summary

This summary is machine-generated.

This study models intercellular calcium waves in glial cells, explaining how calcium signals propagate through gap junctions. The model successfully reproduces experimental data and reveals bistable dynamics contributing to prolonged calcium plateaus.

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Area of Science:

Cellular Biology
Neuroscience
Biophysics

Background:

Intercellular calcium (Ca(2+)) waves are crucial for cell communication.
Inositol trisphosphate (IP(3)) plays a key role in Ca(2+) signaling.
Glial cells exhibit complex responses to various stimuli.

Purpose of the Study:

To develop a two-dimensional model for intercellular Ca(2+) waves.
To investigate the roles of Ca(2+)-induced IP(3) regeneration and IP(3) diffusion through gap junctions.
To reproduce and classify experimental observations in glial cells.

Main Methods:

A two-dimensional mathematical model was developed.
The model incorporates Ca(2+)-induced IP(3) regeneration.
IP(3) diffusion through gap junctions was included.

Main Results:

The model successfully reproduces experimental observations in glial cells, including responses to mechanical stimulation and glutamate.
The model classifies various experimental scenarios, such as mechanical stimulation followed by acetylcholine (ACh) application.
A glial cell model with bistable dynamics (coexisting Ca(2+) oscillation and fixed point) was shown to cause prolonged Ca(2+) signal plateaus in nearby cells.

Conclusions:

The proposed model provides a framework for understanding intercellular Ca(2+) wave propagation in glial networks.
Bistable dynamics in glial cells can lead to sustained Ca(2+) signaling.
The model's ability to reproduce diverse experimental findings highlights its utility in glial cell research.