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[Acquired hemophilia A with rectus abdominis muscle and intrapelvic hematomas after aortic arch replacement]

Mariko Ushiki1, Michiaki Koike, Toshihiro Akiyama

  • 1Department of Hematology, Juntendo University Shizuoka Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|March 8, 2011
PubMed

A 60-year-old man demonstrated a bleeding tendency at enterostomy about 7 months after aortic arch replacement. Abdominal muscle hematoma and pelvic hematoma were also detected. He was diagnosed as having acquired hemophilia A based on prolonged APTT (65.9 sec), reduced FVIII activity (>1%), and the presence of FVIII inhibitor (19.5 BU/ml). Severe anemia was recognized. Recombinant activated factor FVIII (9.6 mg) was administered 25 times, combined with steroid pulse therapy. Usually postoperative acquired hemophilia is recognized in the immediate postoperative period or about 3 months later, while in this case, acquired hemophilia appeared 7 months postoperatively.

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